Fig. 1

Methionine cycle and the biosynthetic pathway of CPC in Acremonium chrysogenum. MTHF, methyltetrahydrofolate; THF, tetrahydrofolate; SAM, S-adenosylmethionine; SAH, S-adenosylhomocysteine; AC, the tripeptide δ-(l-a-aminoadipyl)-l-cysteinyl-d-valine which is catalyzed by ACV synthetase encoded by pcbAB; CPC, cephalosporin C; α-AAA, α-aminoadipic acid