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Fig. 1 | Microbial Cell Factories

Fig. 1

From: Module and individual domain deletions of NRPS to produce plipastatin derivatives in Bacillus subtilis

Fig. 1

a Schematic diagram of the plipastatin biosynthetic system. b Structure of plipastatin. c Deletion strategies: (i) deleting module 6 or 7 in plipastatin NRPS respectively, (ii) Deleting single A6 or A7 domain, (iii) deleting single T6 and T7 domain. Plipastatin NRPS assembly line contains five subunits, encoded by five genes ppsABCDE. Base on their function, the plipastatin synthetase are divided into 10 modules. Each module is comprised of condensation (C), adenylation (A) and thiolation (T) domains. Module 2, 4, 6 and 9 contains an epimerization (E) domian. A thioesterase (Te) domain is located on the C-teminus of module 10, which is responsible for products cyclisation and hydrolysis

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Microbial Cell Factories

ISSN: 1475-2859

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