Fig. 3
From: Corynebacterium glutamicum as platform for the production of hydroxybenzoic acids
Schematic representation of the main modules of the central metabolism of C. glutamicum and introduced modifications for improving hydroxybenzoate synthesis. For an increased production of hydroxybenzoates with C. glutamicum DelAro5, different genetic modifications were introduced. This included increasing the phosphotransferase-independent sugar import with IolT1 and improving the activity of the transketolase Tkt. In parallel, reducing the GltA-mediated citrate synthase activity reduced the activity of the TCA cycle (see text for details)