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Fig. 1 | Microbial Cell Factories

Fig. 1

From: Identification, function, and application of 3-ketosteroid Δ1-dehydrogenase isozymes in Mycobacterium neoaurum DSM 1381 for the production of steroidic synthons

Fig. 1

An overview of proposed pathway for phytosterols degradation in mycobacteria. Phytosterols can be transformed to vary valuable intermediates, including C19-steroids (4-androstene-3,17-dione [AD], 1,4-androstadiene-3,17-dione [ADD], and 9α-hydroxy-4-androsten-3,17-dione [9-OHAD]) and C22-steroids (22-hydroxy-23, 24-bisnorchola-4-en-3-one [4HP], 22-hydroxy-23, 24-bisnorchola-1,4-dien-3-one [HPD] and 9,22-dihydroxy-23,24-bisnorchol-4-ene-3-one [9-OHHP]). KstD, 3-ketosteroid-Δ1-dehydrogenase; KSH, 3-ketosteroid-9α-hydroxylases; CYP125, cytochrome P450 125; CHO, cholesterol oxidase; Hsd4A, 17β-hydroxysteroid dehydrogenase and β-hydroxyacyl-CoA dehydrogenase; FadA5, thiolase FadA5

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