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Fig. 5 | Microbial Cell Factories

Fig. 5

From: Engineering CRISPR interference system in Klebsiella pneumoniae for attenuating lactic acid synthesis

Fig. 5

Bioreactor cultivation of the K. pneumoniae strains harboring CRISPRi system. a Kp(ptac-puuC + pdCas9), recombinant K. pneumoniae strain harboring aldehyde dehydrogenase puuC expression vector and dCas9 expression vector; b Kp(ptac-puuC + placiD), recombinant K. pneumoniae strain harboring aldehyde dehydrogenase puuC expression vector and CRISPRi vector targeting d-lactate dehydrogenase gene ldhA; c Kp(ptac-puuC + placiMALD), recombinant K. pneumoniae strain harboring puuC expression vector and CRISPRi vector targeting four lactate-producing enzyme genes mgsA, aldA, pmb and ldhA. 3-HP, 3-hydroxypropionic acid; LA, lactic acid; AC, acetic acid; 1,3-PDO, 1,3-propanediol; 2, 3-BDO, 2,3-butanediol

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