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Fig. 2 | Microbial Cell Factories

Fig. 2

From: Chemical genomic guided engineering of gamma-valerolactone tolerant yeast

Fig. 2

Chemical genomic profiling of GVL. Chemical genomic profiling of the yeast non-essential deletion mutant collection was used to identify mutants significantly sensitive to GVL (a, n = 3). The p-value of mutants with a decreased fitness in the presence of 2.3% GVL compared to blank medium is plotted on the Y-axis. Of the top 20 significantly responsive mutants, strains annotated to the GO process Late Endosome to Vacuole Transport (GO:0045324) are presented in red. The GVL IC50 of did2Δ, vps38Δ, and sec28Δ versus the control strain was estimated in rich medium (b Mean ± SE, n = 3). ANOVA was used to detect differences in growth

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