Fig. 1
From: Structure-based antigenic epitope and PEGylation improve the efficacy of staphylokinase
The site mutants selected for site PEGylation modified of Sak. a The five residues of Sak monomer selected for site PEGylation modified, Gly79, Leu82, Lys84, Ala97, and Arg104, were marked with sticks (PDB code 2sak). b Shown is the electrostatic potential surface of the monomer Sak (PDB code 2sak) in the same orientation as in a. c The five residues of Sak (Sak-μPl plasminogen complex) selected for site PEGylation modified, Gly79, Leu82, Lys84, Ala97, and Arg104, were marked with sticks (PDB code 1bui). d Shown is the electrostatic potential surface of Sak-μPl plasminogen complex (PDB code 1bui) in the same orientation as in c. Saturating Red indicates A < − 10 kiloteslase/e, and saturating blue indicates A > 10 kiloteslase/e, T = 293K