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Fig. 5 | Microbial Cell Factories

Fig. 5

From: Integrating multi-omics analyses of Nonomuraea dietziae to reveal the role of soybean oil in [(4′-OH)MeLeu]4-CsA overproduction

Fig. 5

Scheme of metabolic pathways in [(4′-OH)MeLeu]4-CsA production under MO condition. Enzymes in red font are activated under MO condition and the rate-limiting enzymes are underlined besides. Regions of different colors represent different metabolic modules. G6PD glucose-6-phosphate dehydrogenase, Edd phosphogluconate dehydratase, KDPG 2-keto-3-deoxy-6-phosphogluconate, PFK 6-phosphofructokinase, ENO enolase, PK pyruvate kinase, DLD dihydrolipoamide dehydrogenase, PDH pyruvate dehydrogenase, CS citrate synthase, DLDH dihydrolipoyl dehydrogenase, SucA alpha-ketoglutarate decarboxylase, SucD succinyl-CoA synthetase alpha subunit, Ndh NADH dehydrogenase, Ald alanine dehydrogenase, LeuA 2-isopropylmalate synthase, GS glutamate synthase, HutU urocanate hydratase, HAL histidine ammonia-lyase, MUT methylmalonyl-CoA mutase, MetK S-adenosylmethionine synthetase, SahH S-adenosyl-l-homocysteine hydrolase, CYP cytochrome P450 hydroxylase, POR P450 oxidoreductase, PheRS phenylalanine–tRNA ligase, GatB aspartyl/glutamyl-tRNA amidotransferase subunit B, ProRS proline–tRNA ligase, TrpRS tryptophanyl-tRNA synthetase, EF-Ts elongation factor Ts

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