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Table 3 Deduced functions of genes in the nocamycin biosynthetic gene cluster

From: Identification of nocamycin biosynthetic gene cluster from Saccharothrix syringae NRRL B-16468 and generation of new nocamycin derivatives by manipulating gene cluster

Gene Length (amino acids) Closest similar protein accession number, origin, identity/similarity (%) Deduced function
Orf1 306 KOX27604, Saccharothrix sp. NRRL B-16348 Short-chain dehydrogenase
Ofr2 664 KOX27605.1, Saccharothrix sp. NRRL B-16348, 81/86% Helicase
Orf3 455 WP_053719771, Saccharothrix sp. NRRL B-16348 Hypothetical protein
NcmM 225 SCD95979, Streptomyces sp. PalvLS-984, 68/79% Transcriptional regulator
NcmL 511 EJI98707, Rhodococcus sp. JVH1, 50/60% Monooxygenase
NcmN 911 AFI57028 (QmnRg4), Amycolatopsis orientalis, 43/55% LuxR family regulator
NcmO 412 AFI57027 (QmnO), Amycolatopsis orientalis, 48/63% Cytochrome P450 oxidase
NcmP 287 ACN29714 (NokK), Nonomuraea longicatena, 44/55% Carboxylate O-methyltransferase
NcmC 272 ADY38535 (TrdC), Streptomyces sp. SCSIO1666, 45/58% Dieckmann cyclase
NcmB 1119 ADY38536 (TrdD), Streptomyces sp. SCSIO1666, 56/66% Non-ribosomal peptide synthetase
NcmD 271 AII10529, Rhodococcus opacus, 45/60% Short-chain dehydrogenase
NcmQ 120 EJY55702, Alicyclobacillus hesperidum URH17-3-68, 41/55% Glyoxalase/bleomycin resistance protein
NcmAI 4915 CBA11584 (SlgA1), Streptomyces lydicus, 54/64% Type I polyketide synthase
NcmAII 1786 EHY88978, Saccharomonospora azurea NA-128, 54/65% Type I polyketide synthase
NcmAIII 1554 CCF23202, Streptomyces hygroscopicus, 60/69% Type I polyketide synthase
NcmAIV 1786 CCF23202.1, Streptomyces hygroscopicus, 56/66% Type I polyketide synthase
NcmAV 2679 AEP40935.1, Nocardiopsis sp. FU40, 50/60% Type I polyketide synthase
NcmE 273 ADC79643 (TamE), Streptomyces sp. 307-9, 60/76% Glycoside hydrolase
NcmF 487 ADY38538 (TrdF), Streptomyces sp. SCSIO1666, 50/61% Prenyltransferase
NcmG 397 ADZ45320(Mur7), Streptomyces sp. NRRL 30471, 51/64% Cytochrome P450 oxidase
NcmH 543 CAH10178 (ChaT1), Streptomyces chartreusis, 42/60% Multiple drug transporter
NcmI 197 KKZ83567, Rhizobium phaseoli Ch24-10, 41/61% PadR family transcriptional regulator
NcmJ 713 WP_037345636, Sciscionella sp. SE31, 69/79% AAA family ATPase
NcmK 213 ADY38543(TrdK) Streptomyces sp. SCSIO1666, 49/64% TetR family transcriptional regulator
Orf4 110 GAT66653, Planomonospora sphaerica, 43/54% Ohr subfamily peroxiredoxin
Orf5 232 GAT10151, Mycobacterium novocastrense, 64/73% Ubiquinone biosynthesis methyltransferase UbiE
Orf6 322 KDO05396, Amycolatopsis mediterranei, 68/77% (2Fe–2S) ferredoxin