Fig. 3From: Improving the production of 22-hydroxy-23,24-bisnorchol-4-ene-3-one from sterols in Mycobacterium neoaurum by increasing cell permeability and modifying multiple genesSchematic profiles of the conversion pathway of sterol to 4-HBC. Sterols share a common and conserved degradation pathway. Here, the cholesterol was used as the model substrate of the sterol catabolism pathway. The disruptions of several enzymes to block the sterol catabolism pathway, resulting in the accumulation of 4-HBC, was colored with green font. The genes colored with red font in the upstream conversion pathway of sterol to 4-HBC were individually overexpressed in the strain WIIIΔmmpL3 Back to article page