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Table 1 Inhibition constants (K I s) of periplasmically produced N-TIMP-1/2 and TIMP-2

From: Direct expression of active human tissue inhibitors of metalloproteinases by periplasmic secretion in Escherichia coli

TIMPs

K I (nM) measured in this study/reported in literatures [21, 24, 25, 27, 28]

Yield (mg/L)

MMP-1

MMP-2

MMP-7

CdMMP-14

N-TIMP-1

0.5

7.21 ± 0.33/0.4–3

10.98 ± 3.76/0.4–1.11

4.62 ± 0.44/3.6 ± 0.9

Not inhibitory/146

N-TIMP-2

1.4

0.65 ± 0.14/0.4 ± 0.1

0.80 ± 0.03/0.04–0.3

2.86 ± 0.94/2–32

3.96 ± 0.53/0.8–3

TIMP-2

0.2

2.51 ± 0.01/NA

0.39 ± 0.09/0.6 ± 0.3

2.74 ± 0.09/NA

0.34 ± 0.04/NA

  1. All K I values are exhibited with ±SE