TY - JOUR AU - Krogerus, Kristoffer AU - Seppänen-Laakso, Tuulikki AU - Castillo, Sandra AU - Gibson, Brian PY - 2017 DA - 2017/04/21 TI - Inheritance of brewing-relevant phenotypes in constructed Saccharomyces cerevisiae × Saccharomyces eubayanus hybrids JO - Microbial Cell Factories SP - 66 VL - 16 IS - 1 AB - Interspecific hybridization has proven to be a potentially valuable technique for generating de novo lager yeast strains that possess diverse and improved traits compared to their parent strains. To further enhance the value of hybridization for strain development, it would be desirable to combine phenotypic traits from more than two parent strains, as well as remove unwanted traits from hybrids. One such trait, that has limited the industrial use of de novo lager yeast hybrids, is their inherent tendency to produce phenolic off-flavours; an undesirable trait inherited from the Saccharomyces eubayanus parent. Trait removal and the addition of traits from a third strain could be achieved through sporulation and meiotic recombination or further mating. However, interspecies hybrids tend to be sterile, which impedes this opportunity. SN - 1475-2859 UR - https://doi.org/10.1186/s12934-017-0679-8 DO - 10.1186/s12934-017-0679-8 ID - Krogerus2017 ER -