Skip to main content
Fig. 3 | Microbial Cell Factories

Fig. 3

From: Expanding metabolic pathway for de novo biosynthesis of the chiral pharmaceutical intermediate l-pipecolic acid in Escherichia coli

Fig. 3

Gene screening for increasing the biosynthetic pool of precursor l-lysine. The concise descriptions of the genes and plasmid construction strategy are on the left with the corresponding results on the right. The filled bar represents OD600, the bar with forward slash represents l-lysine titer (g/L), the bar with backslash represents l-pipecolic acid titer (g/L), the bar with horizontal lines represents l-lysine specific productivity (glysine/g DCW), the unfilled bar represents l-pipecolic acid specific productivity (g l-PA/g DCW). a Screening of single genes for improving the l-lysine metabolic flux. b Screening of gene combinations for improving the l-lysine metabolic flux. c Screening of gene combinations for l-pipecolic acid overproduction

Back to article page