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Fig. 1 | Microbial Cell Factories

Fig. 1

From: Dynamic control of ERG20 expression combined with minimized endogenous downstream metabolism contributes to the improvement of geraniol production in Saccharomyces cerevisiae

Fig. 1

Schematic overview of geraniol biosynthesis based on the mevalonate (MVA) pathway in S. cerevisiae. The endogenous genes tHMG1, IDI1 and ERG20 WW and heterologous gene tVoGES encoding a truncated version of geraniol synthase from Valeriana officinalis were overexpressed to improve geraniol production in our previous work. The native promoter of ERG20 was replaced with the CTR3 promoter, BTS1 promoter or HXT1 promoter. Other engineered genes in this pathway: OYE2, NADPH oxidoreductase and ATF1, alcohol acetyltransferase. HMG-CoA 3-hydroxy-3-methylglutaryl coenzyme A, IPP isopentenyl pyrophosphate, DMAPP dimethylallyl pyrophosphate, GPP geranyl diphosphate, FPP farnesyl diphosphate

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