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Table 1 Cobalamin biosynthetic pathway in microbes

From: Microbial production of vitamin B12: a review and future perspectives

Microorganisms De novo synthesis pathway Salvage pathway References
Aerobes
 Pseudomonas dentrificans Yes Yes [3]
 Rhodobacter capusulatus Yes Yes [3]
 Rhodobacter sphaeroides Yes Yes [3]
 Sinorhizobium meliloti Yes Yes [3]
Anaerobes
 Salmonella typhimurium Yes Yes [4]
 Bacillus megaterium Yes * [5]
 Propionibacterium shermanii Yes * [5]
 Escherichia coli No Yes [4]
 Thermotoga sp. RQ2 No No [6]
 Thermotoga maritima MSB8 No No [6]
 Thermotoga neapolitana No No [6]
 Thermotoga petrophila No No [6]
 Thermotoga naphthophila No No [6]
 Thermotoga thermarum No Yes [6]
 Thermotoga lettingae No Yes [6]
 Fervidobacterium nodosum No Yes [6]
 Thermosipho melanesiensis Yes Yes [6]
 Thermosipho africanus Yes Yes [6]
 Kosmotoga olearia No Yes [6]
 Mesotoga prima No No [6]
 Petrotoga mobilis No No [6]
  1. Unidentified pathways are marked with “*”