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Fig. 3 | Microbial Cell Factories

Fig. 3

From: Engineered biosynthesis of milbemycins in the avermectin high-producing strain Streptomyces avermitilis

Fig. 3

Engineered avermectin-milbemycin hybrid PKSs and predicted milbemycin biosynthetic pathways. a Modular organization in AveA1 and AveA3 replacement strain S. avermitilis SAMA13. b Modular organization in AveA1 and AveA3-module7 replacement strain S. avermitilis SAMA1M7. c Post-PKS tailoring pathway of desired milbemycins. The sequential tailoring steps were shown as orange lines

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