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Table 1 Induction of mRNA expression by IFN-α/Fc fusion proteins in PBMCs

From: Elimination of N-glycosylation by site mutation further prolongs the half-life of IFN-α/Fc fusion proteins expressed in Pichia pastoris

Samples

OAS1

STAT1

IFN-α

19.59

1.67

IFN-α/Fc-WT

10.47

1.34

IFN-α/Fc-MD

10.60

1.41

IFN-α/Fc-SC

10.75

1.23

PEG-IFN-α

11.73

1.26

PBS

1.00

1.00

  1. PBMCs were treated with 10 ng/mL of indicated samples. RNA was extracted and the level of induction was measured relative to untreated cells (PBS) by quantitative PCR
  2. OAS1 2, 5-oligoadenylate synthetase 1, STAT1 signal transducer and activator of transcription 1
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Microbial Cell Factories

ISSN: 1475-2859

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