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Table 1 Growth and production performance of the C. glutamicum strains AVA-1, AVA-2 and AVA-3 during batch cultivation in shake flasks using a mineral salt medium with glucose as sole carbon source

From: Systems metabolic engineering of Corynebacterium glutamicum for the production of the carbon-5 platform chemicals 5-aminovalerate and glutarate

 

C. glutamicum

AVA-1

C. glutamicum

AVA-2

C. glutamicum

AVA-3

Rates

 µ [h−1]

0.22 ± 0.04

0.20 ± 0.00

0.11 ± 0.00

 qs [mmol g−1 h−1]

4.59 ± 0.70

3.67 ± 0.27

2.16 ± 0.07

 qAva [mmol g−1 h−1]

0.43 ± 0.06

0.38 ± 0.01

0.59 ± 0.02

 qGlt [mmol g−1 h−1]

0.57 ± 0.07

0.50 ± 0.00

0.05 ± 0.00

 qLys [mmol g−1 h−1]

0.24 ± 0.04

0.00 ± 0.00

0.00 ± 0.00

Yields

 YX/S [g mol−1]

47.6 ± 3.6

53.9 ± 1.0

51.8 ± 0.5

 YAva/S [mmol mol−1]

97.6 ± 2.0

104.9 ± 1.8

274.9 ± 2.9

 YGlt/S [mmol mol−1]

123.4 ± 2.4

140.7 ± 5.6

21.8 ± 1.4

 YLys/S [mmol mol−1]

52.6 ± 0.9

0.0 ± 0.0

0.0 ± 0.0

  1. The data represent mean values and standard deviations from three biological replicates and denote the specific rates for growth (µ), substrate uptake (qS), and product formation (qP). Additionally, the yield for biomass (YX/S), 5-aminovalerate (YAva/S), glutarate (YGlt/S), and l-lysine (YLys/S) are given