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Fig. 2 | Microbial Cell Factories

Fig. 2

From: Lactococcus lactis carrying the pValac eukaryotic expression vector coding for IL-4 reduces chemically-induced intestinal inflammation by increasing the levels of IL-10-producing regulatory cells

Fig. 2

Body weight variations, damage scores, and histological aspects of colonic tissue from mice administered TNBS. a Percentage of initial body weight of BALB/c mice subjected or not to TNBS administration as function of time (n = 18). b Macroscopic damage score of TNBS-induced colitis in BALB/c mice (n = 18). c Microscopic damage score of TNBS-induced colitis in BALB/c mice (n = 6). d Histological aspect of colonic tissue from BALC/c mice subjected or not to TNBS administration. Long black arrow ulceration; white arrow necrosis; star edema; and short black arrow inflammatory infiltrate. N, negative control; P, positive control; MV, mice that received L. lactis MG1363 (pValac::dts) intragastrically; MI, mice that received L. lactis MG1363 (pValac::dts::IL-4) intragastrically; FV, mice that received L. lactis MG1363 FnBPA+ (pValac::dts) intragastrically; and FI, mice that received L. lactis MG1363 FnBPA+ (pValac::dts::IL-4) intragastrically. a Experimental group whose percentage of initial body weight is significantly different from the percentage of groups P, MV, MI, FV and FI (p < 0.001). b Experimental group whose percentage of initial body weight is significantly different from the percentage of groups N, P, MV, MI and FV (p < 0.001). Data are shown as mean ± SD. p value: *p < 0.05; **p < 0.01; ***p < 0.001

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