Fig. 4
From: Rewiring a secondary metabolite pathway towards itaconic acid production in Aspergillus niger
Growth evaluation of A. niger in the presence of extracellularly added itaconic acid. Growth of AB1.13 CAD strain in M12Â +Â Cu supplemented with several concentrations of itaconic acid. Medium devoid of C-source is used as negative control. An extracellular concentration of 10Â g/L IA in the production medium results in an 75Â % decrease in biomass development. At 20Â g/L IA growth is at sub-inhibitory level and even higher concentrations of IA further deteriorate growth