Fig. 1
From: Rewiring a secondary metabolite pathway towards itaconic acid production in Aspergillus niger
Itaconic acid production pathway in Aspergillus terreus. The itaconic acid biosynthesis pathway in Aspergillus terreus. Glucose is converted to pyruvate through glycolysis. Pyruvate is converted to acetyl-CoA that together with oxaloacetate forms citric acid and start the TCA cycle. MttA transports cis-aconitate from the mitochondrion into the cytosol where CadA facilitates the conversion of cis-aconitic acid to itaconic acid and concomitantly MfsA transports itaconic acid out of the cell. Note that only direct pathway steps towards IA production are shown