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Table 2 Ranking of the critical parameters

From: Development of an accurate kinetic model for the central carbon metabolism of Escherichia coli

Rank

Parameter

Sensitivity

1

\(v_{Pts4}^{\hbox{max} }\)

3.0405

2

\(v_{Nonpts}^{\hbox{max} }\)

0.8187

3

\(v_{G6pdh}^{\hbox{max} }\)

−0.4044

4

k Pfk_cat

0.3947

5

k Mdh1_cat

0.2211

6

k Fbp_cat

−0.1907

7

k Ppc_cat

0.1620

8

k Sdh1_cat

0.1179

9

k Pdh_cat

0.1154

10

k Cs_cat

0.1032

11

k Pyk_cat

−0.0576

12

\(v_{Pta}^{\hbox{max} }\)

0.0473

13

\(v_{6pgdh}^{\hbox{max} }\)

0.0408

14

k Mez_cat

−0.0393

15

\(v_{Ack}^{\hbox{max} }\)

0.0360

16

k Fum1_cat

0.0298

17

\(v_{Edd}^{\hbox{max} }\)

−0.0266

18

k Gapdh_cat

0.0248

19

k Mdh2_cat

0.0135

20

\(v_{Ru5p}^{\hbox{max} }\)

0.0090

21

k Pck_cat

−0.0079

22

k Pps_cat

0.0071

23

k Acs_cat

−0.0066

24

k Fba_cat

0.0061

25

\(v_{TktA}^{\hbox{max} }\)

0.0058

26

k Fum2_cat

0.0056

27

\(v_{TktB}^{\hbox{max} }\)

0.0039

28

\(v_{R5PI}^{\hbox{max} }\)

−0.0021

29

\(v_{Eda}^{\hbox{max} }\)

−0.0021

30

\(v_{Pgi}^{\hbox{max} }\)

0.0016

31

k Sdh2_cat

0.0007

32

\(v_{Tal}^{\hbox{max} }\)

0.0007

33

k Icdh_cat

0.0004

34

\(k_{Glk\_cat}\)

0.0002

35

k αkgdh_cat

0.0002

36

\(v_{Pgl}^{\hbox{max} }\)

−9.54E−07

37

k Ms_cat

6.97E−07

38

k Icl_cat

6.39E−07

  1. The sensitivities were sampled at 6 h. The kinetic parameters were sorted according to their absolute values