Table 1 Chemically synthesized lanthipeptides, analogues and mimics, with corresponding yields
Lanthipeptide, analogue or mimic (lab-scale synthesis) | Amount obtained (mg) | Product yield (%) | No. of steps | Approx. average yield per step (%) | References |
|---|---|---|---|---|---|
Nisin | ND | 0.003a | ND | 70 | [56] |
Lactocin S | 1.5 | 10 | 71 | 97 | [57] |
Lacticin 3147 | 4.8 | 1.0–1.4 | >50 | >95 | [22] |
Lacticin 481 | 2.0 | 1.3 | 52 | 92 | [35] |
Epilancin 15X | 2.0 | 1.6 | 59 | 93 | [58] |
DAP-substituted ring A of lactocin S | 1.5 | 2.5 | >71 | 93 | [44] |
Norleucine substituted lactocin S | 0.8 | 0.8 | >70 | ND | [59] |
Nle, DAP-substituted lactocin S | 1.0 | 1.8 | >70 | ND | [59] |
N-terminal oxazole lactocin S | 0.33 | 0.3 | >70 | ND | [59] |
Alkene substituted lacticin 3147 Ltnβ | 1.8 | 0.5 | 53 | 76 | [40] |
Oxygen substituted lacticin 3147 | 1.1 | 0.3 | 53 | 90 | [41] |
Bis(desmethyl)lacticin 3147 | 1.0 | 1.3 | >50 | 84 | [43] |
LL- diastereomers of lacticin 481 | 1.9 | 1.3 | >53 | 92 | [35] |
N-truncated variant of Epilancin 15X | 1.2 | 1.9 | 45 | 92 | [58] |