Fig. 2

Summary of the major structural features in lanthipeptides biosynthesis and functions. a Schematic representation of one example of each class of lanthipeptide biosynthetic gene clusters, showing conserved motifs between the classes (indicated by vertical lines on designated genes with the same colour). Putative and characterized domains are respectively labeled: Class I (LanB, LanC), II (LanM), III (LanKC) and IV (LanL) processing enzymes install PTMs on their respective precursor peptides (LanA, cloured red). b Structure of ruminococcin A (LanA) precursor peptide showing the core peptide attached to the leader peptide and the side chains of amino acid residues that are targeted by RumM for lanthionine ring formation