Fig. 4

Glycolysis/gluconeogenesis and glycogenolysis/glyconeogenesis in M. maripaludis with associated ORFs. The solid lines show the presence of enzymes in M. maripaludis and dotted lines show their absence. The enzymes corresponding to the various reaction numbers are: 1. carbon-monoxide dehydrogenase (1.2.7.4, codh & porEF); 2. acetyl CoA decarbonylase (2.1.1.245, acds); 3. pyruvate:ferredoxin oxidoreductase/synthase (1.2.7.1, porABCD); 4. acetyl CoA synthetase (AMP forming) (6.2.1.1, acsA); 5. phosphenolpyruvate kinase (2.7.1.40, pyk); 6. enolase (4.2.1.11, eno); 7. 2,3-bisphosphoglycerate mutase (5.4.2.12, pgm); 8. phosphoglycerate kinase (2.7.2.3, pgk); 9. glyceraldehyde-3-phosphate dehydrogenase (1.2.1.59, gapdh); 10. triosephosphate isomerase (5.3.1.1, tpi); 11. fructose-bisphosphate aldolase (4.1.2.13. fbp); 12. phosphofructokinase (2.7.1.147, pfk); 13. glucose-6-phosphate isomerase (5.3.1.9, pgi); 14. Phosphoglucomutase (5.4.2.8, pgm); 15. glycogen phosphorylase (2.4.1.1, glgP); 16. pyruvate carboxylase (6.4.1.1, pycB); 25. phosphoenolpyruvate carboxylase; 26. phosphoenolpyruvate synthase (2.7.9.2, ppsA); 27. NADP-dependent glyceraldehyde-3-phosphate dehydrogenase (1.2.1.9, gapn) OR ferredoxin-dependent glyceraldehyde-3-phosphate dehydrogenase (1.2.7.6, gapor); 28. fructose-bisphosphatase (3.1.3.11, fbp); 29. ADP-specific phosphofructokinase (2.7.1.147, pfk); 30. Transketoloase (2.2.1.1, tkl); 35. Acetate CoA synthetase (ADP-forming) (6.2.1.13, acd); 36. UTP-glucose-1-phosphate uridylyltransferase (2.7.7.9); 37. starch synthase (2.4.1.21, glgA)