Fig. 4
Relative changes in protein abundance (LC-MS/MS) between HP and WT strains for two time points. The changes in abundance on the level of biological processes are presented as log2 of the ratio between HP and WT with red fields representing increased abundance in HP and green fields representing decreased abundance in HP. Proteins are grouped according to their functional annotations in KEGG and abundance levels of group-wise averages are shown. Ery, proteins of the ery cluster; TCA, enzymes of the TCA cycle. Proteins of the ery cluster are strongly upregulated, as are some of the enzymes responsible for the synthesis of aliphatic amino acids. Enzymes of the TCA cycle are downregulated. Proteins of the pks6 and tpc4 secondary metabolic clusters are upregulated in HP while proteins of the pks2 and pks8 clusters are downregulated. Abundance changes for individual proteins belonging to each of these groups are presented in Additional file 9