Fig. 2

Numbers of differentially expressed genes and differentially abundant proteins at the four bioprocess time points. The numbers of up-regulated genes/proteins in HP compared to WT strain at the time points t1 to t4 of the fermentation process are shown in red and down-regulated in green. Darker colour is used for microarray analyses of gene expression and lighter colour for LC–MS/MS analyses of protein abundance. The cut-off for differential expression was |logFC| > 1 and p < 0.01 and for differential protein abundance was |logFC| > 1.5, respectively. Due to extensive proteolysis in the HP strain samples differential protein abundance was not calculated at t3 and t4