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Fig. 1 | Microbial Cell Factories

Fig. 1

From: Production of para-aminobenzoic acid from different carbon-sources in engineered Saccharomyces cerevisiae

Fig. 1

Simplified shikimate pathway including modifications for pABA production. Knock-out targets are highlighted red, (over)expression targets green. The central intermediates are: 3-deoxy-d-arabino-heptulosonate-7-phosphate (DAHP), 3-dehydroquinate (DHQ), 3-dehydroshikimate (DHS), shikimate, shikimate-3-phosphate (S3P), chorismate, phenylalanine (PHE), tyrosine (TYR), tryptophan (TRP) and para-aminobenzoate (pABA). Important genes and the respective enzymes involved are: ARO3/ARO4: 3-deoxy-d-arabino-heptulosonate-7-phosphate (DAHP) synthase, ARO7: chorismate mutase, TRP2: anthranilate synthase, TRP3: indole-3-glycerol-phosphate synthase, ABZ1: aminodeoxychorismate synthase, ABZ2: aminodeoxychorismate lyase

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Microbial Cell Factories

ISSN: 1475-2859

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