From: Improving the N-terminal diversity of sansanmycin through mutasynthesis
Fed substrate (3Â mM) | Sansanmycin analogue | Production level (%) |
---|---|---|
─ | sansanmycin MX-4 | 100 |
m-Tyr | sansanmycin A | ~350 |
Phe | sansanmycin MX-4 | ~280 |
2-Cl/Br-Phe | compound 1, 2 | 240–270 |
2-Furyl-Ala | sansanmycin MX-7 | ~240 |
Tyr | sansanmycin MX-2 | ~80 |
2-Thienyl-Ala | sansanmycin MX-8 | ~35 |
4-NH2-Phe | sansanmycin MX-9 | ~30 |