Fig. 5

Clustering of flux deviations. Matrix of deviation from the average for 19 fluxes and all strains (a). Each rectangle of the matrix represents a relative deviation index calculated by dividing the deviation between the flux of one reaction for one strain and the average flux for all strains by the average flux of the corresponding reaction. Each line corresponds to all relative deviation indexes for one strain. Each column corresponds to the relative deviation indexes for one reaction and all strains. The lines and column are ordered with respect to the function of their Euclidian distances, which are represented by dendrograms both at the top and the left of the matrix. The distribution of all the relative deviation indexes as well as the corresponding color gradient are in the top left of the matrix. The sub-graphs represent the effect of strain origin on the relative deviation index as well as the distribution of the corresponding flux for eight selected fluxes (red distribution for fluxes constrained by experimental data, and blue for fluxes only predicted by the model) (b–i). Simplified schematic representation of the metabolic network (j–m). The relative deviation index for four selected strains of different origins is indicated as a percentage. Only the deviations greater than ±8 % are provided