Table 1 Proposed functions of paulomycin biosynthesis cluster deduced proteins from S. albus J1074

SSHG_05310

RNA polymerase sigma factor

Pau1 (98/98)

PauY1 (98/99)

SSHG_05311

M23 family peptidase

Pau2 (99/100)

PauY2 (99/100)

SSHG_05312

Putative aminotransferase

Pau3 (100/100)

PauY3 (99/99)

SSHG_05313

Plm1

TetR-family transcriptional regulator

Pau4 (99/100)

PauY4 (100/100)

SSHG_05314

Plm2

LuxR-family transcriptional regulator

Pau5 (94/94)

PauY5 (96/96)

SSHG_05315

Plm3

Isovaleryltransferase

Pau6 (100/100)

PauY6 (99/99)

SSHG_05316

Plm4

Oxidoreductase

Pau7 (100/100)

PauY7 (98/99)

SSHG_05317

Plm5

Conserved hypothetical protein

Pau8 (100/100)

PauY8 (100/100)

SSHG_05318

Plm6

EmrB/QacA subfamily transporter

Pau9 (100/100)

PauY9 (99/99)

SSHG_05319

Plm7

Elongation factor G 1

Pau10 (99/99)

PauY10 (99/99)

SSHG_05320

Plm8

Dehydrogenase E1 alpha subunit

Pau11 (100/100)

PauY11 (99/99)

SSHG_05321

Plm9

Dehydrogenase E1 beta subunit

Pau12 (99/99)

PauY12 (99/99)

SSHG_05322

Plm10

SARP-family transcriptional regulator

Pau13 (99/100)

PauY13 (100/100)

SSHG_05323

Plm11

Cytochrome P450-like

Pau14 (99/99)

PauY14 (98/99)

SSHG_05324

Plm12

Glycosyltransferase

Pau15 (99/99)

PauY15 (99/99)

SSHG_05325

Plm13

NDP-hexose 2,3-dehydratase

Pau16 (99/99)

PauY16 (99/99)

SSHG_05326

Plm14

3-hydroxybenzoate 6-hydroxylase

Pau17 (99/100)

PauY17 (99/99)

SSHG_05327

Plm15

Anthranilate synthase

Pau18 (99/99)

PauY18 (99/99)

SSHG_05328

Plm16

Isochorismatase

Pau19 (99/99)

PauY19 (99/99)

SSHG_05329

Plm17

2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase

Pau20 (99/99)

PauY20 (99/99)

SSHG_05330

Plm18

3-deoxy-D-arabino-heptulosonate-7-phosphate synthase

Pau21 (99/99)

PauY21 (99/99)

SSHG_05331

Plm19

Predicted GCN5-related N-acetyltransferase

–

–

SSHG_05332

Plm20

dTDP-glucose 4,6-dehydratase

Pau22 (99/99)

PauY22 (99/99)

SSHG_05333

Plm21

D-glucose-1-phosphate synthase

Pau23 (99/99)

PauY23 (99/99)

SSHG_05334

Plm22

Isovaleryltransferase

Pau24 (99/99)

PauY24 (99/99)

SSHG_05335

Plm23

C-glycosyltransferase

Pau25 (100/100)

PauY25 (99/99)

SSHG_05336

Plm24

Glyoxalase

Pau26 (99/100)

PauY26 (99/100)

SSHG_05337

Plm25

FAD-binding monooxygenase

Pau27 (99/100)

PauY27 (99/99)

SSHG_05338

Plm26

Hypothetical protein, Reductase

Pau28 (99/99)

PauY28 (99/99)

SSHG_05339

Plm27

3-oxoacyl-ACP synthase III

Pau29 (99/99)

PauY29 (100/100)

SSHG_05340

Plm28

Putative sulfotransferase

Pau30 (100/100)

PauY30 (99/98)

SSHG_05341

Plm29

Aminotransferase

Pau31 (99/100)

PauY31 (98/98)

SSHG_05342

Plm30

LuxR-family transcriptional regulator

Pau32 (100/100)

PauY32 (100/100)

SSHG_05343

Plm31

Oxidoreductase

Pau33 (99/99)

PauY33 (98/98)

SSHG_05344

Plm32

Acyl-CoA synthase

Pau34 (99/99)

PauY34 (100/100)

SSHG_05345

Plm33

Acyl-carrier protein

Pau35 (100/100)

PauY35 (100/100)

SSHG_05346

Plm34

Dihydrodipicolinate reductase

Pau36 (100/100)

PauY36 (100/100)

SSHG_05347

Plm35

Ribulose-5-phosphate 4-epimerase

Pau37 (99/99)

PauY37 (100/100)

SSHG_05348

Plm36

4′-phosphopantetheinyl transferase

Pau38 (99/99)

PauY38 (100/100)

SSHG_05349

Plm37

Acyl-CoA dehydrogenase

Pau39 (99/100)

PauY39 (99/99)

SSHG_05350

Plm38

Hypothetical protein

Pau40 (98/100)

PauY40 (97/99)

SSHG_05351

Plm39

Pyranose oxidase

Pau41 (100/100)

PauY41 (100/100)

SSHG_05352

Plm40

dTDP-4-keto-6-deoxy-L-hexose 2,3-reductase

Pau42 (99/99)

PauY42 (99/99)

SSHG_05353

Plm41

dTDP-6-deoxy-L-hexose 3-O- methyltransferase

Pau43 (100/100)

PauY43 (100/100)

SSHG_05354

Plm42

dTDP-4-keto-6-deoxyhexose 3,5-epimerase

Pau44 (100/100)

PauY44 (100/100)

SSHG_05355

Malate synthase

Pau45 (99/100)

PauY45 (99/100)

SSHG_05356

Oxidoreductase

Pau46 (97/98)

PauY46 (98/98)

SSHG_05357

Oxidoreductase

Pau47 (100/100)

PauY47 (99/99)