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Fig. 9 | Microbial Cell Factories

Fig. 9

From: New insights into paulomycin biosynthesis pathway in Streptomyces albus J1074 and generation of novel derivatives by combinatorial biosynthesis

Fig. 9

Characterization of genes involved in paulic acid biosynthesis. UPLC chromatograms, monitored at 244 nm, of S. albus J1074 mutant strains altered in paulomycins biosynthesis by inactivation of plm28 (SAM5340) and plm29 (SAM5341) involve in paulic acid biosynthesis. Extracts were generated by culturing mutant strains in R5A liquid medium during 96 h. Labeled peaks correspond to paulomycin A (1), paulomycin B (2), paulomycin E (3), paulomenol A (4), paulomenol B (5), 2-aminobenzoic acid (anthranilic acid) (8), N-acetyl-orto-aminobenzoic acid (10), deoxydehydrochorismic acid (11)

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Microbial Cell Factories

ISSN: 1475-2859

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