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Fig. 7 | Microbial Cell Factories

Fig. 7

From: New insights into paulomycin biosynthesis pathway in Streptomyces albus J1074 and generation of novel derivatives by combinatorial biosynthesis

Fig. 7

Proposed paulomycin A and B biosynthesis pathway (Route A). Orthologues from S. paulus NRRL8115 [33] are depicted in parenthesis. Last step in paulomycose by incorporation of a pyruvate unit has been previously characterized biochemically in C4-branched 3,6-dideoxyhexose yersiniose A biosynthesis [38]. ADIC, 2-amino-2-deoxyisochorismate; DAHP, 3-deoxy-D-arabinose-heptulosonic 7-phosphate; DHHA, 2,3-dihydro-3-hydroxyanthranilate; E4P, erythrose-4-phosphate; 3-HAA, 3-hydroxyanthranilic acid; PEP, phosphoenolpyruvate

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