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Fig. 2 | Microbial Cell Factories

Fig. 2

From: New insights into paulomycin biosynthesis pathway in Streptomyces albus J1074 and generation of novel derivatives by combinatorial biosynthesis

Fig. 2

Paulomycin biosynthesis gene cluster. a S. albus J1074 genome region containing the paulomycin biosynthesis gene cluster. Bars represent genes at cluster boundaries analyzed by RT-PCR. b RT-PCR gene expression analysis of genes delimiting paulomycin biosynthesis gene cluster boundaries: sshg_05312, sshg_05313 (plm1), sshg_05314 (plm2), sshg_05315 (plm3), sshg_05353 (plm41), sshg_05354 (plm42) sshg_05355 and sshg_05356. c UPLC chromatograms, monitored at 244 nm, of S. albus J1074 and SAM5314, SAM5312, SAM5313 and SAM5355 mutant strains. Labeled peaks correspond to paulomycins A (1), B (2) and E (3), and paulomenols A (4) and B (5)

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Microbial Cell Factories

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