Fig. 5
Transcriptome and metabolic flux analyses in the central carbon metabolism in ST687 and ST1 (non-producer) strains. The differentially expressed genes in ST687 compared with ST1 are highlighted with color. All the fluxes were normalized to the glucose uptake flux (set as 1). The values in the first and second lines correspond to the flux distributions in ST687 and ST1 strains, respectively. Black numbers are fluxes calculated from 13C analysis and grey numbers are predicted fluxes from the genome-scale model. glc glucose, g6p glucose-6-phosphate, 6pgl d-6-phospho-glucono-δ-lactone, 6pgc 6-phospho-d-gluconate, ru5p ribulose-5-phosphate, xu5p xylulose-5-phosphate, s7p sedoheptulose-7-phosphate, e4p erythrose-4-phosphate, r5p ribose-5-phosphate, f6p fructose-6-phosphate, fdp fructose-1,6-diphosphate, g3p glyceraldehyde-3-phosphate, dhap dihydroxy-acetone phosphate, glyc3p glycerol-3-phosphate, glyc glycerol, 13dpg 1,3-diphosphateglycerate, 3pg 3-phosphoglycerate, 2pg 2-phosphoglycerate, pep phosphoenolpyruvate, pyr pyruvate, acald acetaldehyde, etoh ethanol, acc acetate, accoa acetyl-CoA, malcoa malonyl-CoA, 3hp 3-hydroxypropionic acid, cit citrate, icit isocitrate, akg α-ketoglutarate, succoa succinyl-CoA, succ succinate, fum fumarate, mal malate, oaa oxaloacetate