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Fig. 8 | Microbial Cell Factories

Fig. 8

From: Characterization and engineering of the biosynthesis gene cluster for antitumor macrolides PM100117 and PM100118 from a marine actinobacteria: generation of a novel improved derivative

Fig. 8

Characterization of cytochrome P450 monooxygenase gene gonCP. a UPLC analysis of PM100117 (1) and PM100118 (2) production in Streptomyces caniferus GUA-06-05-006A wild type (GUA) and ΔgonCP mutant. Peaks with an absorption spectrum related to PM100117 and PM100118 derivatives are tagged with triangles. b Chemical structures of PM100117 and PM100118 derivatives lacking a keto functional group of the macrolactone moiety. Asterisks indicate the point where the PM100117 and PM100118 chemical structures have been modified

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Microbial Cell Factories

ISSN: 1475-2859

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