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Table 3 Representative examples of supportive protein drugs in cancer

From: Recombinant pharmaceuticals from microbial cells: a 2015 update

Drug name Cell factory Biological role Mechanism of action Indications
Filgrastim (Scimax) E. coli Cytokine Stimulates hematopoiesis Bone marrow transplantation and cancer chemotherapy induced neutropenia
Pegfilgrastim (Neupeg) E. coli Cytokine Stimulates differentiation, proliferation and activation of the neutrophilic granulocytes Cancer chemotherapy induced neutropenia
Darbepoetin alfa (Aranesp) CHO cells Hormone Stimulates processes of erythropoiesis or red blood cell production Anemia associated with chronic renal failure, cancer chemotherapy or heart failure. Myelodysplastic syndrome
Lenograstim (CERBIOS) CHO cells Cytokine Stimulates differentiation, proliferation and activation of neutrophilic granulocytes Neutropenia associated with cytotoxic therapy or bone marrow transplantation
Epoetin alfa (Binocrit) CHO cells Hormone Stimulates production of oxygen carrying red blood cells from the bone marrow Anemia associated with chronic renal failure and cancer chemotherapy induced anemia