From: Recombinant pharmaceuticals from microbial cells: a 2015 update
Drug name | Cell factory | Biological role | Mechanism of action | Indications |
---|---|---|---|---|
Filgrastim (Scimax) | E. coli | Cytokine | Stimulates hematopoiesis | Bone marrow transplantation and cancer chemotherapy induced neutropenia |
Pegfilgrastim (Neupeg) | E. coli | Cytokine | Stimulates differentiation, proliferation and activation of the neutrophilic granulocytes | Cancer chemotherapy induced neutropenia |
Darbepoetin alfa (Aranesp) | CHO cells | Hormone | Stimulates processes of erythropoiesis or red blood cell production | Anemia associated with chronic renal failure, cancer chemotherapy or heart failure. Myelodysplastic syndrome |
Lenograstim (CERBIOS) | CHO cells | Cytokine | Stimulates differentiation, proliferation and activation of neutrophilic granulocytes | Neutropenia associated with cytotoxic therapy or bone marrow transplantation |
Epoetin alfa (Binocrit) | CHO cells | Hormone | Stimulates production of oxygen carrying red blood cells from the bone marrow | Anemia associated with chronic renal failure and cancer chemotherapy induced anemia |