Skip to main content

Table 2 Top ten selling protein biopharmaceuticals in 2014

From: Recombinant pharmaceuticals from microbial cells: a 2015 update

Druga Active ingredient Molecule Sales in billions Origin
Humira Adalimumab Recombinant human monoclonal antibody 12.54 CHO
Sovaldi Sofosbuvir Nucleotide analogue polymerase (NS5B) inhibitor 10.28 Chemical
Remicade Infliximab Recombinant chimeric, humanized tumor necrosis factor alpha (TNF) monoclonal antibody 9.24 Hybridoma cell line
Rituxan Rituximab Recombinant humanized monoclonal antibody 8.68 CHO
Enbrel Etanercept Recombinant soluble dimeric fusion protein 8.54 CHO
Lantus Insulin glargine Insulin receptor agonist 7.28 E. coli
Avastin Bevacizumab Recombinant humanized antibody 6.96 CHO
Herceptin Trastuzumab Recombinant humanized monoclonal antibody 6.79 CHO
Advair Fluticasone propionate and salmeterol xinafoate Glucocorticoid receptor agonist and β-2 adrenergic receptor agonist 6.43 Chemical
Crestor Rosuvastatin calcium Antihyperlipedemic agent 5.87 Synthetic
  1. aData according to, November 2015