Table 2 Top ten selling protein biopharmaceuticals in 2014
From: Recombinant pharmaceuticals from microbial cells: a 2015 update
Druga | Active ingredient | Molecule | Sales in billions | Origin |
|---|---|---|---|---|
Humira | Adalimumab | Recombinant human monoclonal antibody | 12.54 | CHO |
Sovaldi | Sofosbuvir | Nucleotide analogue polymerase (NS5B) inhibitor | 10.28 | Chemical |
Remicade | Infliximab | Recombinant chimeric, humanized tumor necrosis factor alpha (TNF) monoclonal antibody | 9.24 | Hybridoma cell line |
Rituxan | Rituximab | Recombinant humanized monoclonal antibody | 8.68 | CHO |
Enbrel | Etanercept | Recombinant soluble dimeric fusion protein | 8.54 | CHO |
Lantus | Insulin glargine | Insulin receptor agonist | 7.28 | E. coli |
Avastin | Bevacizumab | Recombinant humanized antibody | 6.96 | CHO |
Herceptin | Trastuzumab | Recombinant humanized monoclonal antibody | 6.79 | CHO |
Advair | Fluticasone propionate and salmeterol xinafoate | Glucocorticoid receptor agonist and β-2 adrenergic receptor agonist | 6.43 | Chemical |
Crestor | Rosuvastatin calcium | Antihyperlipedemic agent | 5.87 | Synthetic |