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Table 1 Recombinant biopharmaceuticals approved in the 1980s

From: Recombinant pharmaceuticals from microbial cells: a 2015 update

Product Cell factory Therapeutic indication Year
Humulin E. coli Diabetes 1982
Protropin E. coli hGH deficiency 1985
Roferon A E. coli Hairy cell leukaemia 1986
IntronA E. coli Cancer, genital warts and hepatitis 1986
Recombivax S. cerevisiae Hepatitis B 1986
Orthoclone OKT3 Hybridoma cell line Reversal of acute kidney and transplant rejection 1986
Humatrope E. coli hGH deficiency 1987
Activase CHO Acute myocardial infarction 1987
Epogen CHO Anaemia 1989