TY - JOUR AU - Tang, Xin AU - Zan, Xinyi AU - Zhao, Lina AU - Chen, Haiqin AU - Chen, Yong Q. AU - Chen, Wei AU - Song, Yuanda AU - Ratledge, Colin PY - 2016 DA - 2016/02/11 TI - Proteomics analysis of high lipid-producing strain Mucor circinelloides WJ11: an explanation for the mechanism of lipid accumulation at the proteomic level JO - Microbial Cell Factories SP - 35 VL - 15 IS - 1 AB - The oleaginous fungus, Mucor circinelloides, is attracting considerable interest as it produces oil rich in γ-linolenic acid. Nitrogen (N) deficiency is a common strategy to trigger the lipid accumulation in oleaginous microorganisms. Although a simple pathway from N depletion in the medium to lipid accumulation has been elucidated at the enzymatic level, global changes at protein levels upon N depletion have not been investigated. In this study, we have systematically analyzed the changes at the levels of protein expression in M. circinelloides WJ11, a high lipid-producing strain (36 %, lipid/cell dry weight), during lipid accumulation. SN - 1475-2859 UR - https://doi.org/10.1186/s12934-016-0428-4 DO - 10.1186/s12934-016-0428-4 ID - Tang2016 ER -