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Table 2 Gene deletion lethality predictions by iMAC868 model of M. acetivorans compared with predictions of previous models

From: Assessing methanotrophy and carbon fixation for biofuel production by Methanosarcina acetivorans

Gene deletion

Acetate

Methanol

References

iVS941

iMB745

iMAC868

iVS941

iMB745

iMAC868

ΔackΔpta

NGNG

NGNG

NGNG

GG

GG

GG

[30]

ΔhdrABC

GG

GG

GG

GG

GG

GG

[70]

ΔhdrED

GNG

NGNG

NGNG

GNG

NGNG

NGNG

[70]

Δmch

GNG

GNG

NGNG

NGNG

NGNG

NGNG

[46]

ΔmtaA1

GG

GG

GG

NGNG

NGNG

NGNG

[45]

ΔmtaB 1C1ΔmtaB 2C2ΔmtaB 3C3

GG

GG

GG

NGNG

NGNG

NGNG

[45]

ΔmtaA1ΔmtaB 1C1ΔmtaB 2C2ΔmtaB 3C3

GNG

GNG

GNG

NGNG

NGNG

NGNG

[45]

ΔmtbA

GG

GG

GG

GG

GG

GG

[45]

ΔmtsDΔmtsFΔmtsH

GG

GG

GG

GG

GG

GG

[71]

ΔmtsXΔmtsY, X and Y any two mts genes

GG

GG

GG

GG

GG

GG

[71]

ΔrnfHCDGEABF

GNG

NGNG

NGNG

GG

GG

GG

[70]

ΔlysK

GG

GG

GG

GG

GG

GG

[72]

ΔlysS

GG

GG

GG

GG

GG

GG

[72]

Δmtr

GNG

NGNG

NGNG

NGNG

NGNG

NGNG

[73]

Total correct

9/14

12/14

13/14

13/14

14/14

14/14

 
  1. GG growth in silico/growth in vivo, GNG growth in silico/no growth in vivo, NGNG no growth in silico/no growth in vivo