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Fig. 5 | Microbial Cell Factories

Fig. 5

From: Oral delivery of Lactococcus lactis that secretes bioactive heme oxygenase-1 alleviates development of acute colitis in mice

Fig. 5

The modulating effect of NZ-HO on the expression of cytokines in colonic tissue. On day 8, protein extracts and total RNA were prepared from the middle and proximal colons, respectively. Protein levels of IL-6 (A), TNF-α (B), and IL-10 (D), and the mRNA expression of IL-1α (C) were analyzed with ELISA (A, B, D) or real-time qPCR (C). Data from ELISA are the mean + SE (n = 5–10). Values for the real-time qPCR analysis are shown as a box plot (n = 5–10). Letters (i.e., a, b, c) represent significant differences (P < 0.05). nd not detected

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