Fig. 8From: Mammalian prion protein (PrP) forms conformationally different amyloid intracellular aggregates in bacteriaEvolution of PrPWT aggregates morphology during in vitro aggregation. After purification and refolding PrPWT was converted into amyloid fibrils as described in “Methods”. The aggregates morphology was assessed at different times by negative staining and transmission electron microscopy. Scale bars 0.2 μm (10 h), 0.5 μm (24 h), and 0.5 μm (72 h)Back to article page