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Fig. 2 | Microbial Cell Factories

Fig. 2

From: Identification of novel tylosin analogues generated by a wblA disruption mutant of Streptomyces ansochromogenes

Fig. 2

Effects of wblA disruption on nikkomycin production. a The bioassay of nikkomycin against Alternaria longipes. b The bioassay of nikkomycin against Candida albicans. c HPLC analysis of nikkomycin. d Transcription analysis of genes related to nikkomycin biosynthesis by qRT-PCR; the transcript of hrdB was used as an internal control. (I): ΔwblA, (II): S. ansochromogenes 7100, (III): complemented strain by integrating a copy of wblA into the chromosome of ΔwblA, (IV): the control strain by integrating pSET152 vector into the chromosome of ΔwblA. Arrows indicate the peak of nikkomycin on HPLC produced by S. ansochromogenes 7100

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