Fig. 7

Migration of human dermal fibroblasts induced by native and yeast-derived human CRTs. a Primary human dermal fibroblasts were plated, wounded, treated with increasing doses of native placental or recombinant human CRTs (0.1–10 ng/ml) and assayed for wound closure after 24 h, as described in methods. Experiments were performed in triplicate. Error bars represent standard deviation (n = 1). b Primary human dermal fibroblasts were plated, wounded, treated with increasing concentrations of CRT (1–100 ng/ml), and assayed for wound closure at 6 h. Experiments were performed in triplicate (n = 2). Error bars represent standard error of the mean. A Dunnett’s test for statistical significance was performed (*p ≤ 0.05, **p ≤ 0.01, and ***p ≤ 0.001)