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Table 1 Insecticidal activity of the mixture of 1 and 2 compared with those of milbemycins A3/A4 and ivermectin

From: Designed biosynthesis of 25-methyl and 25-ethyl ivermectin with enhanced insecticidal activity by domain swap of avermectin polyketide synthase

Samples

LC50 (μg/ml)c

C. elegans

M. separata

The mixture of 1 and 2 a

2.2 ± 0.7

19.4 ± 1.3

Milbemycin A3/A4b

5.4 ± 2.1

110.7 ± 7.4

Ivermectin

10.1 ± 1.3

 
  1. aThe mixture contains 70 % compound 1 and 30 % compound 2
  2. bMilbemycins A3/A4 contains 70 % A4 and 30 % A3
  3. cValues are the means ± SDs of three independent experiments