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Table 1 Maximum theoretical yield of resveratrol on glucose, depending on co-factor specificity of specific enzymes

From: Growth-rate dependency of de novo resveratrol production in chemostat cultures of an engineered Saccharomyces cerevisiae strain

Active proteins (co-factor specificity)

\({\text{Y}}_{\text{P/S}}^{\hbox{max} }\)

ATP

mol mol−1

Glyc (mol)

TCA (mol)

OxPh (mol)

Total (mol)

Ald6 (NADP) and Gdh2 (NAD)

0.284

2.875

0.875

9.25

13

Ald6 (NADP) and Gdh1/3 (NADP)

0.282

2.750

0.750

9.50

13

Ald2/3 (NAD) and Gdh2(NAD)

0.279

2.500

0.500

10.00

13

Ald2/3 (NAD) and Gdh1/3 (NADP)

0.277

2.375

0.375

10.25

13

  1. A stoichiometric model was used to determine the maximum theoretical yield of resveratrol on glucose, and to calculate the ATP demand per mol of product by summing the ATP produced in glycolysis (Glyc), the citric acid cycle (TCA) and by oxidative phosphorylation (OxPh)