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Fig. 5 | Microbial Cell Factories

Fig. 5

From: Recombinant antibody production evolves into multiple options aimed at yielding reagents suitable for application-specific needs

Fig. 5

Salmonella as a tumor-targetable cargo. Salmonella can be transformed for displaying recombinant antibodies specific for tumor cell antigens and for secreting enzymes able to activate pro-drugs. The antibodies assure the selective accumulation of systematically provided bacteria in the antigen-expressing target tissue and there the secreted enzymes will trigger the local conversion of inactive pro-drug into toxic compounds with anti-tumor activity

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