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Table 1 Recombinant proteins produced in LAB for biomedical purposes

From: Lactic acid bacteria: reviewing the potential of a promising delivery live vector for biomedical purposes

LAB

Application

Recombinant protein

Expression vector

Promoter

Protein display

References

Lactococcus lactis

IDB

Anti-TNFalpha nanobodies

pTREX-derived

P1 (pH dependent)

Secreted

[22]

Lactococcus lactis

IDB

Trefoil Factors (TFF)

pTREX-derived

P1 (pH dependent)

Secreted

[23]

Lactococcus lactis

IDB

Low calcium response V (LcrV)

pNZYR-derived

PUsp45 (constitutive)

Secreted

[21]

Lactobacillus gasseri/Lactobacillus casei

IDB

Superoxide Dismutase (SOD)

pSodA

pILKSsodA

sodA native promoter

–

[39, 40]

Lactococcus lactis

IDB

IL-10

Cromosome integrated

PthyA (constitutive)

Secreted

[26]

Lactococcus lactis

IDB

IL-27

pT1NX-derived

P1 (pH dependent)

Secreted

[35]

Lactococcus lactis

IBD

Murine IL-10

pLB263

PgroESL (Inducible)

Secreted

[15]

Lactococcus lactis/Lactobacillus casei

IDB/colorectal Cancer

Catalase

pSEC:KatE/pLEM415mnkat

PnisA (inducible)/Pldh (constitutive)

Cytoplasmatic

[24, 25]

Lactococcus lactis

Type 1 diabetes

Pro Insulin/(GAD)-65/IL-10

pT1NX-derived

P1 (pH dependent)

Secreted

[44]

Lactococcus lactis

Type 1 diabetes

HSP65-6P277

pCYT:HSP65-6P277/pHJ: HSP65-6P277

PnisA (inducible)/constitutive

Cytoplasmatic/secreted

[43]

Lactococcus lactis

Type 1 diabetes

GAD65 and IA-2

–

–

Secreted

[46]

Lactococcus lactis

Diabetes

Single-chain insulin analog, SCI-57

pNZPnisA:uspSCI-57

PnisA (inducible)

Secreted

[41]

Lactococcus lactis

Type 2 diabetes

Glucagon like peptide-1 (GLP-1)

pUBGLP-1

P1 (pH dependent)

Secreted

[42]

Lactococcus lactis

Cancer

HPV-16 E7 antigen

pLB263

PgroESL (inducible)

Secreted

[15]

Bifidobacterium longum

Breast cancer

Cytosine Deaminase

pBLES100-S-eCD

–

–

[57]

Bifidobacterium adolescentis

Cancer

Endostatin

pBV220-derived

PRPL (thermoinducible)

Cytoplasmatic

[58]

Bifidobacterium breve

Cancer treatment study tool

Luciferase

pLux MC3

Phelp (constitutive)

Cytoplasmatic

[59]

Lactococcus lactis

Cervical cancer

HPV-16 E7

–

PnisA (Inducible)

Anchored

[61]

Lactococcus lactis

Cervical cancer

HPV-16 E7

pMG36e

P32 (constitutive)

Cytoplasmatic

[62]

Lactococcus lactis/Lactobacillus casei

Cervical cancer

HPV-16 E7

–

–

Anchored

[63]

Bacillus subtilis

Cervical cancer

HPV33 L1

pICHPV33L1-NS/B

Pxylose (inducible)

Intracellular

[74]

Lactobacillus paracasei

Bacillus anthracis infection

Antibody fragment

pAF100-derived/pAF400-derived/pAF900-derived

P apf (constitutive)

Secreted/attached/cell anchored

[85]

Lactobacillus paracasei

Rotavirus infection

Antibody fragment

pLP501-derived

Pldh (constitutive)

Secreted/cell anchored

[87]

Bifidubacterium longum

Enterovirus 71 infection

VP1

pBBADs-VP1

–

–

[109]

Bifidubacterium longum

Hepatitis C infection

HCV-NS3 peptide

–

–

Cell anchored

[110]

Lactococcus lactis

Staphylococal infection

Staphylocococal nuclease

pLB263

PgroESL (inducible)

Secreted

[15]

Lactobacillus acidophilus

HIV infection

Gag

pTRK1035

(Constitutive)

Cell anchored

[82]

Lactobacillus jensenii

HIV infection

two-domain CD4 (2D CD4) proteins

pOSEL144

P23 (constitutive)

Secreted

[69]

Lactobacillus casei

Tetanus

Tetanus toxin fragment C (TTC)

pLP401-TTFC

P amylase (inducible)

Cell anchored

[72]

Lactobacillus casei

Tetanus

Tetanus toxin fragment C (TTC)

pLP501-TTFC

Pldh (constitutive)

Cell anchored

[72]

Lactobacillus plantarum

Tetanus

Tetanus toxin fragment C (TTC)

pMEC160

Pldh (constitutive)

Cell anchored

[70]

Streptococcus gordonii

Clostridium tetani infection

Tetanus toxin fragment C

pSMB158

(constitutive)

Cell anchored

[111]

Lactobacillus acidophilus

Helicobacter pylori infection

Adhesin Hp0410

pMG36e

–

Cytoplasmatic

[76]

Lactococcus lactis

Rotavirus infection

VP8

pNZ8048

PnisA (inducible)

Secreted/cell anchored/cytoplasmatic

[112]

Lactococcus lactis

Malaria

MSP-119

pL2-PSGT

–

Cytoplasmatic

[81]

Lactococcus lactis

Peanut allergy

Ara h 2

pNZ8148

PnisA (inducible)

Secreted/cell anchored/cytoplasmatic

[93]

Lactococcus lactis

Dust mite allergy

Der p2

pNZ8148

PnisA (inducible)

Secreted/cell anchored/cytoplasmatic

[94]

Streptococcus gordonii

Giardia lamblia infection

cyst wall protein 2 (CWP2)

pSMB104

(constitutive)

Cell anchored

[73]

Lactobacillus zeae

Streptococcus mutants infection

ScFv protein

pLP402-scFv

–

Cell anchored

[68]

Lactococcus lactis

Streptococcus pneumoniae infection

Pneumococcal surface protein A

pTREX1

P1 (pH dependent)

Cytoplasmatic

[113]

Lactobacillus casei

SARS-associated coronavirus infection

PgsA and spike protein

pHAT

PHCE (constitutive)

Cell anchored

[114]

Lactobacillus acidophilus

Chiken anemia virus

VP1

pETacmA1

–

Cell anchored

[71]

Lactococcus lactis

Avian influenza virus

hemagglutinin 1 (HA1)

pMG36e

–

Cytoplasmatic

[91]

Lactococcus lactis

Leishmania major infection

LACK

LACK + IL12

pDL-PnisA

PnisA (inducible)

Secreted/cell anchored/cytoplasmatic

[88]

Lactobacillus casei

Pancreatic necrosis virus (IPNV)

VP2/VP3

pG1/pG2

Pxylose (inducible)

Secreted

[89, 90]

Lactococcus lactis

Body weight control

Leptin

pSEC:lep

PnisA (Inducible)

–

[97]

Saccharomyces cerevisiae

Hypercalcemia

Salmon calcitonin

pAGA2-sCT

PGAL1 (inducible)

Cell anchored

[115]