LAB | Application | Recombinant protein | Expression vector | Promoter | Protein display | References |
---|---|---|---|---|---|---|
Lactococcus lactis | IDB | Anti-TNFalpha nanobodies | pTREX-derived | P1 (pH dependent) | Secreted | [22] |
Lactococcus lactis | IDB | Trefoil Factors (TFF) | pTREX-derived | P1 (pH dependent) | Secreted | [23] |
Lactococcus lactis | IDB | Low calcium response V (LcrV) | pNZYR-derived | PUsp45 (constitutive) | Secreted | [21] |
Lactobacillus gasseri/Lactobacillus casei | IDB | Superoxide Dismutase (SOD) | pSodA pILKSsodA | sodA native promoter | – | |
Lactococcus lactis | IDB | IL-10 | Cromosome integrated | PthyA (constitutive) | Secreted | [26] |
Lactococcus lactis | IDB | IL-27 | pT1NX-derived | P1 (pH dependent) | Secreted | [35] |
Lactococcus lactis | IBD | Murine IL-10 | pLB263 | PgroESL (Inducible) | Secreted | [15] |
Lactococcus lactis/Lactobacillus casei | IDB/colorectal Cancer | Catalase | pSEC:KatE/pLEM415mnkat | PnisA (inducible)/Pldh (constitutive) | Cytoplasmatic | |
Lactococcus lactis | Type 1 diabetes | Pro Insulin/(GAD)-65/IL-10 | pT1NX-derived | P1 (pH dependent) | Secreted | [44] |
Lactococcus lactis | Type 1 diabetes | HSP65-6P277 | pCYT:HSP65-6P277/pHJ: HSP65-6P277 | PnisA (inducible)/constitutive | Cytoplasmatic/secreted | [43] |
Lactococcus lactis | Type 1 diabetes | GAD65 and IA-2 | – | – | Secreted | [46] |
Lactococcus lactis | Diabetes | Single-chain insulin analog, SCI-57 | pNZPnisA:uspSCI-57 | PnisA (inducible) | Secreted | [41] |
Lactococcus lactis | Type 2 diabetes | Glucagon like peptide-1 (GLP-1) | pUBGLP-1 | P1 (pH dependent) | Secreted | [42] |
Lactococcus lactis | Cancer | HPV-16 E7 antigen | pLB263 | PgroESL (inducible) | Secreted | [15] |
Bifidobacterium longum | Breast cancer | Cytosine Deaminase | pBLES100-S-eCD | – | – | [57] |
Bifidobacterium adolescentis | Cancer | Endostatin | pBV220-derived | PRPL (thermoinducible) | Cytoplasmatic | [58] |
Bifidobacterium breve | Cancer treatment study tool | Luciferase | pLux MC3 | Phelp (constitutive) | Cytoplasmatic | [59] |
Lactococcus lactis | Cervical cancer | HPV-16 E7 | – | PnisA (Inducible) | Anchored | [61] |
Lactococcus lactis | Cervical cancer | HPV-16 E7 | pMG36e | P32 (constitutive) | Cytoplasmatic | [62] |
Lactococcus lactis/Lactobacillus casei | Cervical cancer | HPV-16 E7 | – | – | Anchored | [63] |
Bacillus subtilis | Cervical cancer | HPV33 L1 | pICHPV33L1-NS/B | Pxylose (inducible) | Intracellular | [74] |
Lactobacillus paracasei | Bacillus anthracis infection | Antibody fragment | pAF100-derived/pAF400-derived/pAF900-derived | P apf (constitutive) | Secreted/attached/cell anchored | [85] |
Lactobacillus paracasei | Rotavirus infection | Antibody fragment | pLP501-derived | Pldh (constitutive) | Secreted/cell anchored | [87] |
Bifidubacterium longum | Enterovirus 71 infection | VP1 | pBBADs-VP1 | – | – | [109] |
Bifidubacterium longum | Hepatitis C infection | HCV-NS3 peptide | – | – | Cell anchored | [110] |
Lactococcus lactis | Staphylococal infection | Staphylocococal nuclease | pLB263 | PgroESL (inducible) | Secreted | [15] |
Lactobacillus acidophilus | HIV infection | Gag | pTRK1035 | (Constitutive) | Cell anchored | [82] |
Lactobacillus jensenii | HIV infection | two-domain CD4 (2D CD4) proteins | pOSEL144 | P23 (constitutive) | Secreted | [69] |
Lactobacillus casei | Tetanus | Tetanus toxin fragment C (TTC) | pLP401-TTFC | P amylase (inducible) | Cell anchored | [72] |
Lactobacillus casei | Tetanus | Tetanus toxin fragment C (TTC) | pLP501-TTFC | Pldh (constitutive) | Cell anchored | [72] |
Lactobacillus plantarum | Tetanus | Tetanus toxin fragment C (TTC) | pMEC160 | Pldh (constitutive) | Cell anchored | [70] |
Streptococcus gordonii | Clostridium tetani infection | Tetanus toxin fragment C | pSMB158 | (constitutive) | Cell anchored | [111] |
Lactobacillus acidophilus | Helicobacter pylori infection | Adhesin Hp0410 | pMG36e | – | Cytoplasmatic | [76] |
Lactococcus lactis | Rotavirus infection | VP8 | pNZ8048 | PnisA (inducible) | Secreted/cell anchored/cytoplasmatic | [112] |
Lactococcus lactis | Malaria | MSP-119 | pL2-PSGT | – | Cytoplasmatic | [81] |
Lactococcus lactis | Peanut allergy | Ara h 2 | pNZ8148 | PnisA (inducible) | Secreted/cell anchored/cytoplasmatic | [93] |
Lactococcus lactis | Dust mite allergy | Der p2 | pNZ8148 | PnisA (inducible) | Secreted/cell anchored/cytoplasmatic | [94] |
Streptococcus gordonii | Giardia lamblia infection | cyst wall protein 2 (CWP2) | pSMB104 | (constitutive) | Cell anchored | [73] |
Lactobacillus zeae | Streptococcus mutants infection | ScFv protein | pLP402-scFv | – | Cell anchored | [68] |
Lactococcus lactis | Streptococcus pneumoniae infection | Pneumococcal surface protein A | pTREX1 | P1 (pH dependent) | Cytoplasmatic | [113] |
Lactobacillus casei | SARS-associated coronavirus infection | PgsA and spike protein | pHAT | PHCE (constitutive) | Cell anchored | [114] |
Lactobacillus acidophilus | Chiken anemia virus | VP1 | pETacmA1 | – | Cell anchored | [71] |
Lactococcus lactis | Avian influenza virus | hemagglutinin 1 (HA1) | pMG36e | – | Cytoplasmatic | [91] |
Lactococcus lactis | Leishmania major infection | LACK LACKÂ +Â IL12 | pDL-PnisA | PnisA (inducible) | Secreted/cell anchored/cytoplasmatic | [88] |
Lactobacillus casei | Pancreatic necrosis virus (IPNV) | VP2/VP3 | pG1/pG2 | Pxylose (inducible) | Secreted | |
Lactococcus lactis | Body weight control | Leptin | pSEC:lep | PnisA (Inducible) | – | [97] |
Saccharomyces cerevisiae | Hypercalcemia | Salmon calcitonin | pAGA2-sCT | PGAL1 (inducible) | Cell anchored | [115] |