From: Metabolic network capacity of Escherichia coli for Krebs cycle-dependent proline hydroxylation
wt_pET | ΔputA_pET | wt_p4h1of | ΔputA_p4h1of | |||||
---|---|---|---|---|---|---|---|---|
−Pro | +Pro | −Pro | +Pro | −Pro | +Pro | −Pro | +Pro | |
Catabolisma | ||||||||
NADPH | 6.4 | 8.0 | 6.8 | 6.8 | 6.6 | 6.2 | 6.4 | 4.7 |
NADH | 17.8 | 19.1 | 18.5 | 17.7 | 19.2 | 17.6 | 19.3 | 12.9 |
FADH2 | 2.1 | 3.7 | 2.5 | 2.5 | 3.0 | 2.9 | 3.1 | 1.7 |
ATP/GTP | 14.1 | 14.5 | 14.3 | 13.4 | 14.1 | 13.3 | 14.3 | 10.1 |
Biomass formation | ||||||||
NADPH | −7.3 | −7.9 | −7.0 | −7.3 | −5.7 | −5.7 | −5.2 | −5.4 |
NADH | 1.2 | 1.3 | 1.1 | 1.2 | 0.9 | 0.9 | 0.8 | 0.8 |
FADH2 | – | – | – | – | – | – | – | – |
ATP | −7.3 | −8.1 | −7 | −7.3 | −5.4 | −5.4 | −4.9 | −5.1 |
Transhydrogenation | ||||||||
NADPH | 0.9 | −0.1 | 0.2 | 0.5 | −0.9 | −0.5 | −1.2 | 0.7 |
NADH | −0.9 | 0.1 | −0.2 | −0.5 | 0.9 | 0.5 | 1.2 | −0.7 |
Oxidative phosphorylation | ||||||||
NADPH | – | – | – | – | – | – | – | – |
NADH | −18.1 | −20.5 | −19.4 | −18.4 | −21.0 | −19.0 | −21.3 | −13.0 |
FADH2 | −2.1 | −3.7 | −2.5 | −2.5 | −3.0 | −2.9 | −3.1 | −1.7 |
ATP | 58.4 | 67.3 | 63.3 | 60.1 | 68.9 | 62.3 | 70.0 | 42.5 |
Maintenanceb | ||||||||
ATP | −65.2 | −73.7 | −70.6 | −66.2 | −77.6 | −70.2 | −79.4 | −47.5 |